Supernatural Main Characters

Starring

 * Jared Padalecki as Sam Winchester
 * Jensen Ackles as Dean Winchester

Main Villain

 * Azazel

Starring

 * Jared Padalecki as Sam Winchester
 * Jensen Ackles as Dean Winchester

Main Villain

 * Azazel

Starring

 * Jared Padalecki as Sam Winchester
 * Jensen Ackles as Dean Winchester
 * Katie Cassidy as Ruby
 * Lauren Cohan as Bela Talbot

Main Villain

 * Lilith

Starring

 * Jared Padalecki as Sam Winchester
 * Jensen Ackles as Dean Winchester

Main Villain

 * Lilith

Starring

 * Jared Padalecki as Sam Winchester
 * Jensen Ackles as Dean Winchester
 * Misha Collins as Castiel

Main Villain

 * Lucifer

Starring

 * Jared Padalecki as Sam Winchester
 * Jensen Ackles as Dean Winchester
 * Misha Collins as Castiel

Main Villains

 * Raphael
 * Crowley
 * Eve
 * Castiel

Starring

 * Jared Padalecki as Sam Winchester
 * Jensen Ackles as Dean Winchester

Main Villain

 * Dick Roman

Starring

 * Jared Padalecki as Sam Winchester
 * Jensen Ackles as Dean Winchester

Main Villain

 * Crowley

Starring

 * Jared Padalecki as Sam Winchester
 * Jensen Ackles as Dean Winchester
 * Misha Collins as Castiel

Main Villains

 * Metatron
 * Abaddon

Starring

 * Jared Padalecki as Sam Winchester
 * Jensen Ackles as Dean Winchester
 * Misha Collins as Castiel
 * Mark A. Sheppard as Crowley

Main Villains

 * The Mark of Cain
 * Rowena

Starring

 * Jared Padalecki as Sam Winchester
 * Jensen Ackles as Dean Winchester
 * Misha Collins as Castiel
 * Mark A. Sheppard as Crowley

Main Villain

 * Amara / The Darkness

Starring

 * Jared Padalecki as Sam Winchester
 * Jensen Ackles as Dean Winchester
 * Mark A. Sheppard as Crowley
 * Mark Pellegrino as Lucifer
 * Misha Collins as Castiel

Main Villains

 * Doctor Hess
 * Lucifer

Starring

 * Jared Padalecki as Sam Winchester
 * Jensen Ackles as Dean Winchester
 * Mark Pellegrino as Lucifer
 * Alexander Calvert as Jack
 * Misha Collins as Castiel

Main Villains

 * Alternate Michael
 * Lucifer

Starring

 * Jared Padalecki as Sam Winchester
 * Jensen Ackles as Dean Winchester
 * Mark Pellegrino as Nick
 * Alexander Calvert as Jack
 * Misha Collins as Castiel

Main Villain

 * Alternate Michael